Microbiological evaluation for antifungal activity of some metal oxides nanofillers incorporated into cold cured soft lining materials: clinical based study

Objective: The aim of the current study was to evaluate efficacy addition zirconium oxide (ZrO2), titanium oxide(TiO2), and silica (SiO2) nanoparticles cold-cured soft liner on adhesion Candida albicans (CA). Material andMethods: Fifty-four patients had been selected divided into three groups according modification linerwith ZrO2, TiO2, SiO2 (18 each of). Each patient received maxillary complete denture having threecavities, cavities were lined using cold cured modified with different concentration (0%, 3%, 7%) ofmetal nanoparticles. On days 14 28, swaps taken out from relining site immediately cultured forfungal evaluation. number colonies counted, data collected explored for normality Shapiro-Wilktest, logarithmic transformation CA count performed. Repeated one-way ANOVA used followed byTukey HSD. Independent-t test compare between counts at periods. Results: adhesionwas significantly decreased by TiO2 in comparison control group, alsothe antifungal coverage increased (P<0.005). highest wasidentified group while showed lowest (P <0.001). Conclusion: Additionof nanoparticles; is an effective method reducing adhesion.KEYWORDSAntifungal agent; albicans; Denture liners; Nanoparticles.